A new adaptation of the Resident Evil franchise is set to reach cinemas this September, with scenes filmed in Prague now featured in the film’s first official trailer.

The project marks a turning point for director Zach Cregger, who has quickly built a reputation in the horror genre. His earlier films, Barbarian and Weapons, gained attention for their original storytelling and strong audience response, helping establish him as a filmmaker to watch.

This time, Cregger takes on Resident Evil, a series long considered difficult to adapt successfully for the screen. Previous attempts by Sony Pictures struggled to win over both critics and fans. The earlier film series starring Milla Jovovich failed to deliver consistent results, while a recent reboot and a Netflix series also fell short of expectations.

The newly released trailer suggests a different approach. Rather than following a specific storyline from the games, the film introduces a new protagonist played by Austin Abrams, known for his role in Euphoria.

He portrays a courier tasked with delivering a mysterious package to an isolated hospital. The mission quickly turns into a fight for survival as he encounters infected creatures in a hostile environment.

The film is scheduled to premiere in Czech cinemas on September 17.

Several Prague locations feature prominently in the teaser’s action scenes.

One of the most visible is the area under the Negrelli Viadukt in Karlín, where a nighttime sequence shows a snow-covered underpass overtaken by zombies. Brief shots capture Abrams running through the space as the attack unfolds.

Another key set piece appears in Holešovice on Přístavní Street, where Prague 7 was transformed into a damaged urban zone filled with wrecked cars, snow effects and practical gore.

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